3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 330786-24-8)

Application and positioning

The pyrazolo[3,4-d]pyrimidin-4-amine core of ibrutinib, with the 4-phenoxyphenyl group already installed at C-3. The 4-amino group is the hinge binder; the next step is N-1 alkylation with the piperidine fragment. Laurand supplies it from audited Chinese producers in kilogram to multi-hundred-kilogram lots; process and regulatory documentation is coordinated case by case with the manufacturing site.

Quality and documentation

• Batch-specific Certificate of Analysis with HPLC purity and a full impurity profile
• Chiral purity by chiral HPLC where the molecule carries defined stereocentres
• Residual solvent data against ICH Q3C and elemental impurity data against ICH Q3D on request
• Structure confirmation by NMR and MS on first shipments
• SDS in the language of your market, with GHS classification for the destination

Packaging and handling

• 1 kg, 5 kg and 25 kg fibre drums with inner PE liner; amber glass bottles for gram quantities
• Sealed, dry and protected from light; cold-chain arrangement discussed per product where the intermediate requires it
• Store at ambient temperature in a dry warehouse, away from oxidising agents and moisture

Related products

• 4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine (CAS 941685-27-4)
• 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carbonitrile (CAS 924898-13-5)
• 4-(Aminocarbonyl)-N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine (CAS 623950-02-7)
• 4-(Piperidin-4-yl)morpholine (CAS 53617-35-9)
• Ibrutinib (CAS 936563-96-1)

Values marked (predicted) are calculated estimates; the rest are published literature or supplier data. Where a property has no published value we leave it blank rather than estimate it. The specification of the delivered lot is confirmed with the quotation.