2,3-Dimethyl-2H-indazol-6-amine (CAS 444731-72-0)

Application and positioning

The indazole amine that anchors pazopanib — its N2-methyl regiochemistry is the critical quality attribute of this intermediate. Regioisomer content stated explicitly on the COA; ≥99% HPLC. Laurand supplies it from audited Chinese producers in kilogram to multi-hundred-kilogram lots; process and regulatory documentation is coordinated case by case with the manufacturing site.

Quality and documentation

• Batch-specific Certificate of Analysis with HPLC purity and a full impurity profile
• Chiral purity by chiral HPLC where the molecule carries defined stereocentres
• Residual solvent data against ICH Q3C and elemental impurity data against ICH Q3D on request
• Structure confirmation by NMR and MS on first shipments
• SDS in the language of your market, with GHS classification for the destination

Packaging and handling

• 1 kg, 5 kg and 25 kg fibre drums with inner PE liner; amber glass bottles for gram quantities
• Sealed, dry and protected from light; cold-chain arrangement discussed per product where the intermediate requires it
• Store at ambient temperature in a dry warehouse, away from oxidising agents and moisture

Related products

• 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile (CAS 1153949-38-2)
• (R)-9-(2-Hydroxypropyl)adenine (CAS 14047-28-0)
• 6-Iodo-1H-indazole (CAS 261953-36-0)
• (2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide (CAS 1192651-49-2)
• Pazopanib Hydrochloride (CAS 635702-64-6)

Values marked (predicted) are calculated estimates; the rest are published literature or supplier data. Where a property has no published value we leave it blank rather than estimate it. The specification of the delivered lot is confirmed with the quotation.