Ponatinib Hydrochloride (CAS 1114544-31-8)
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Ponatinib Hydrochloride
CAS No. 1114544-31-8
盐酸泊那替尼
Chemical structure
| CAS No. | 1114544-31-8 |
|---|---|
| Synonyms | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide |
| Category | Anti-Cancer API / Anti-Cancer |
| Assay / Purity | 99% |
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.0 |
| Melting Point | — |
| Boiling Point | — |
| Density | — |
| Flash Point | — |
| Appearance | Pale yellow to white solid powder |
Application and positioning
Ponatinib hydrochloride is a third-generation BCR-ABL1 tyrosine kinase inhibitor with activity against the T315I gatekeeper mutation, supplied as the hydrochloride salt. It is used in oral tablets for chronic myeloid leukaemia and Philadelphia-chromosome-positive acute lymphoblastic leukaemia. Laurand supplies it from audited Chinese production partners for pharmaceutical manufacturing and process development.
Quality and documentation
- Batch-specific Certificate of Analysis issued by the manufacturing site
- SDS/MSDS and specification sheet available on request
- Residual solvents and elemental impurities statements discussed per project
- For pharmaceutical manufacturing and R&D use only — not for direct administration
Packaging and handling
- Packed in double polyethylene-lined fibre drums; pack size confirmed at quotation
- Small quantities in sealed aluminium foil bags
- Palletised for air and sea freight; store dry, ventilated and protected from light
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Specifications shown are indicative. The final specification and documentation package are confirmed with the quotation.
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Request a QuoteReference: CAS 1114544-31-8 · PubChem CID 46908927