Acalabrutinib, ACP-196 (CAS 1420477-60-6)
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Acalabrutinib, ACP-196 CAS NO.:1420477-60-6
CAS No. 1420477-60-6
阿可替尼
Chemical structure
| CAS No. | 1420477-60-6 |
|---|---|
| Synonyms | 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide; ACP-196 |
| Category | Anti-Cancer API / Anti-Cancer |
| Assay / Purity | 99% |
| Molecular Formula | C26H23N7O2 |
| Molecular Weight | 465.5 |
| Melting Point | — |
| Boiling Point | — |
| Density | — |
| Flash Point | — |
| Appearance | Off-white to white solid powder |
Application and positioning
Acalabrutinib is a second-generation covalent Bruton's tyrosine kinase (BTK) inhibitor with high selectivity for BTK over EGFR and other kinases. It is used in oral capsules and tablets for chronic lymphocytic leukaemia, small lymphocytic lymphoma and mantle cell lymphoma. Laurand supplies it from audited Chinese production partners for pharmaceutical manufacturing and process development.
Quality and documentation
- Batch-specific Certificate of Analysis issued by the manufacturing site
- SDS/MSDS and specification sheet available on request
- Residual solvents and elemental impurities statements discussed per project
- For pharmaceutical manufacturing and R&D use only — not for direct administration
Packaging and handling
- Packed in double polyethylene-lined fibre drums; pack size confirmed at quotation
- Small quantities in sealed aluminium foil bags
- Palletised for air and sea freight; store dry, ventilated and protected from light
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Specifications shown are indicative. The final specification and documentation package are confirmed with the quotation.
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Request a QuoteReference: CAS 1420477-60-6 · PubChem CID 71226662