4-(4-Amino-3-chlorophenoxy)-N-methylpicolinamide (CAS 284462-44-8)

Application and positioning

The diaryl ether intermediate carrying the 4-chloropyridine-2-carboxamide group of sorafenib and regorafenib. Amine content titrated alongside HPLC assay; suitable for both originator and generic API routes. Laurand supplies it from audited Chinese producers in kilogram to multi-hundred-kilogram lots; process and regulatory documentation is coordinated case by case with the manufacturing site.

Quality and documentation

• Batch-specific Certificate of Analysis with HPLC purity and a full impurity profile
• Chiral purity by chiral HPLC where the molecule carries defined stereocentres
• Residual solvent data against ICH Q3C and elemental impurity data against ICH Q3D on request
• Structure confirmation by NMR and MS on first shipments
• SDS in the language of your market, with GHS classification for the destination

Packaging and handling

• 1 kg, 5 kg and 25 kg fibre drums with inner PE liner; amber glass bottles for gram quantities
• Sealed, dry and protected from light; cold-chain arrangement discussed per product where the intermediate requires it
• Store at ambient temperature in a dry warehouse, away from oxidising agents and moisture

Related products

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• Regorafenib Hydrate (CAS 1019206-88-2)

Values marked (predicted) are calculated estimates; the rest are published literature or supplier data. Where a property has no published value we leave it blank rather than estimate it. The specification of the delivered lot is confirmed with the quotation.