Lorlatinib (CAS 1454846-35-5)
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Lorlatinib
CAS No. 1454846-35-5
洛拉替尼
Chemical structure
| CAS No. | 1454846-35-5 |
|---|---|
| Synonyms | (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile |
| Category | Anti-Cancer API / Anti-Cancer |
| Assay / Purity | 99% |
| Molecular Formula | C21H19FN6O2 |
| Molecular Weight | 406.4 |
| Melting Point | — |
| Boiling Point | — |
| Density | — |
| Flash Point | — |
| Appearance | Off-white to white solid powder |
Application and positioning
Lorlatinib is a third-generation, CNS-penetrant inhibitor of ALK and ROS1 with broad coverage of ALK resistance mutations. It is used in oral tablets for ALK-positive non-small cell lung cancer, including patients progressing on earlier ALK inhibitors. Laurand supplies it from audited Chinese production partners for pharmaceutical manufacturing and process development.
Quality and documentation
- Batch-specific Certificate of Analysis issued by the manufacturing site
- SDS/MSDS and specification sheet available on request
- Residual solvents and elemental impurities statements discussed per project
- For pharmaceutical manufacturing and R&D use only — not for direct administration
Packaging and handling
- Packed in double polyethylene-lined fibre drums; pack size confirmed at quotation
- Small quantities in sealed aluminium foil bags
- Palletised for air and sea freight; store dry, ventilated and protected from light
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Specifications shown are indicative. The final specification and documentation package are confirmed with the quotation.
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Request a QuoteReference: CAS 1454846-35-5 · PubChem CID 71731823